Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior

Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior

IntroductionChemotherapy-induced cognitive impairment colloquially referred to as chemobrain is a poorly understood phenomenon affecting a highly variable proportion of patients with breast cancer. Here we investigate the association between anxiety and despair-like behaviors in mice treated with cy...

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Bibliographic Details
Main Authors: Christa Corley, Taylor McElroy, Bhavana Sridharan, Madison Trujillo, Pilar Simmons, Sangam Kandel, Delawrence J. Sykes, Michael S. Robeson, Antiño R. Allen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Neuroscience
Subjects:
cyclophosphamide
methotrexate
5-fluorouracil
hippocampus
amygdala
microbiome
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1212791/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2023.1212791/full

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