Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

Infusion reactions (IRs) create a translational hurdle for many novel therapeutics, including those utilizing nanotechnology. Nucleic acid nanoparticles (NANPs) are a novel class of therapeutics prepared by rational design of relatively short oligonucleotides to self-assemble into various programmab...

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Bibliographic Details
Main Authors: Enping Hong, Justin R. Halman, Ankit Shah, Edward Cedrone, Nguyen Truong, Kirill A. Afonin, Marina A. Dobrovolskaia
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
nanoparticles
nucleic acids
NANPs
infusion reaction
interferon
immunotoxicity
Toll-like receptors
Online Access:https://www.mdpi.com/1420-3049/24/6/1094

Internet

https://www.mdpi.com/1420-3049/24/6/1094

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