In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway
The extrathoracic oral airway is not only a major mechanical barrier for pharmaceutical aerosols to reach the lung but also a major source of variability in lung deposition. Using computational fluid dynamics, deposition of 1–30 µm particles was predicted in 11 CT-based models of the oral airways of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/160 |
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| author | Azadeh A. T. Borojeni Wanjun Gu Bahman Asgharian Owen Price Andrew P. Kuprat Rajesh K. Singh Sean Colby Richard A. Corley Chantal Darquenne |
| author_facet | Azadeh A. T. Borojeni Wanjun Gu Bahman Asgharian Owen Price Andrew P. Kuprat Rajesh K. Singh Sean Colby Richard A. Corley Chantal Darquenne |
| author_sort | Azadeh A. T. Borojeni |
| collection | DOAJ |
| description | The extrathoracic oral airway is not only a major mechanical barrier for pharmaceutical aerosols to reach the lung but also a major source of variability in lung deposition. Using computational fluid dynamics, deposition of 1–30 µm particles was predicted in 11 CT-based models of the oral airways of adults. Simulations were performed for mouth breathing during both inspiration and expiration at two steady-state flow rates representative of resting/nebulizer use (18 L/min) and of dry powder inhaler (DPI) use (45 L/min). Consistent with previous in vitro studies, there was a large intersubject variability in oral deposition. For an optimal size distribution of 1–5 µm for pharmaceutical aerosols, our data suggest that >75% of the inhaled aerosol is delivered to the intrathoracic lungs in most subjects when using a nebulizer but only in about half the subjects when using a DPI. There was no significant difference in oral deposition efficiency between inspiration and expiration, unlike subregional deposition, which shows significantly different patterns between the two breathing phases. These results highlight the need for incorporating a morphological variation of the upper airway in predictive models of aerosol deposition for accurate predictions of particle dosimetry in the intrathoracic region of the lung. |
| first_indexed | 2024-03-09T11:28:02Z |
| format | Article |
| id | doaj.art-e9e82bd53ec540fd965974a08309918e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:28:02Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e9e82bd53ec540fd965974a08309918e2023-11-30T23:58:33ZengMDPI AGPharmaceutics1999-49232023-01-0115116010.3390/pharmaceutics15010160In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral AirwayAzadeh A. T. Borojeni0Wanjun Gu1Bahman Asgharian2Owen Price3Andrew P. Kuprat4Rajesh K. Singh5Sean Colby6Richard A. Corley7Chantal Darquenne8Department of Medicine, University of California, San Diego, CA 92093-0623, USADepartment of Medicine, University of California, San Diego, CA 92093-0623, USAApplied Research Associates, Arlington Division, Raleigh, NC 27615-2963, USAApplied Research Associates, Arlington Division, Raleigh, NC 27615-2963, USAPacific Northwest National Laboratory, Richland, WA 99352, USAPacific Northwest National Laboratory, Richland, WA 99352, USAPacific Northwest National Laboratory, Richland, WA 99352, USAPacific Northwest National Laboratory, Richland, WA 99352, USADepartment of Medicine, University of California, San Diego, CA 92093-0623, USAThe extrathoracic oral airway is not only a major mechanical barrier for pharmaceutical aerosols to reach the lung but also a major source of variability in lung deposition. Using computational fluid dynamics, deposition of 1–30 µm particles was predicted in 11 CT-based models of the oral airways of adults. Simulations were performed for mouth breathing during both inspiration and expiration at two steady-state flow rates representative of resting/nebulizer use (18 L/min) and of dry powder inhaler (DPI) use (45 L/min). Consistent with previous in vitro studies, there was a large intersubject variability in oral deposition. For an optimal size distribution of 1–5 µm for pharmaceutical aerosols, our data suggest that >75% of the inhaled aerosol is delivered to the intrathoracic lungs in most subjects when using a nebulizer but only in about half the subjects when using a DPI. There was no significant difference in oral deposition efficiency between inspiration and expiration, unlike subregional deposition, which shows significantly different patterns between the two breathing phases. These results highlight the need for incorporating a morphological variation of the upper airway in predictive models of aerosol deposition for accurate predictions of particle dosimetry in the intrathoracic region of the lung.https://www.mdpi.com/1999-4923/15/1/160computational fluid dynamics (CFD)inertial impactionlaryngeal particle depositionoropharyngeal deposition |
| spellingShingle | Azadeh A. T. Borojeni Wanjun Gu Bahman Asgharian Owen Price Andrew P. Kuprat Rajesh K. Singh Sean Colby Richard A. Corley Chantal Darquenne In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway Pharmaceutics computational fluid dynamics (CFD) inertial impaction laryngeal particle deposition oropharyngeal deposition |
| title | In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway |
| title_full | In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway |
| title_fullStr | In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway |
| title_full_unstemmed | In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway |
| title_short | In Silico Quantification of Intersubject Variability on Aerosol Deposition in the Oral Airway |
| title_sort | in silico quantification of intersubject variability on aerosol deposition in the oral airway |
| topic | computational fluid dynamics (CFD) inertial impaction laryngeal particle deposition oropharyngeal deposition |
| url | https://www.mdpi.com/1999-4923/15/1/160 |
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