Activating mutations of the oncogene EZH2 in cutaneous melanoma revealed by next generation sequencing

Activating mutations of the oncogene EZH2 in cutaneous melanoma revealed by next generation sequencing

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase that promotes tumorigenesis by epigenetic repression of tumor suppressor genes. Although EZH2 is overexpressed in many malignancies, activating EZH2 mutations have been described predominantly in follicular lymphoma and diffuse large...

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Bibliographic Details
Main Authors: Paul W. Harms, Alexandra C. Hristov, David S. Kim, Tobenna Anens, Michael J. Quist, Javed Siddiqui, Shannon Carskadon, Rohit Mehra, Douglas R. Fullen, Timothy M. Johnson, Arul M. Chinnaiyan, Nallasivam Palanisamy
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Human Pathology: Case Reports
Subjects:
EZH2
Melanoma
Transcriptome sequencing
Lymphoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2214330014200228

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http://www.sciencedirect.com/science/article/pii/S2214330014200228

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