The AQP2 mutation V71M causesnephrogenic diabetes insipidus in humans but does not impair the function of a bacterial homolog

Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causesnephrogenic diabetes insipidus in humans, on aquaporin structure and activity, u...

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Bibliographic Details
Main Authors: Noreen Klein, Nadine Kümmerer, Dominika Hobernik, Dirk Schneider
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:FEBS Open Bio
Subjects:
Online Access:https://doi.org/10.1016/j.fob.2015.07.003