GDF11 alleviates neointimal hyperplasia in a rat model of artery injury by regulating endothelial NLRP3 inflammasome activation and rapid re-endothelialization

GDF11 alleviates neointimal hyperplasia in a rat model of artery injury by regulating endothelial NLRP3 inflammasome activation and rapid re-endothelialization

Abstract Background Neointimal hyperplasia induced by interventional surgery can lead to progressive obliteration of the vascular lumen, which has become a major factor affecting prognosis. The rate of re-endothelialization is known to be inversely related to neointima formation. Growth differentiat...

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Bibliographic Details
Main Authors: Lei Li, Yan Gao, Zhenchuan Liu, Chenglai Dong, Wenli Wang, Kaiqin Wu, Shaorui Gu, Yongxin Zhou
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Translational Medicine
Subjects:
Growth differentiation factor 11
Re-endothelialization
NLRP3 inflammasome
LOX-1
Neointima formation
Online Access:https://doi.org/10.1186/s12967-022-03229-6

Internet

https://doi.org/10.1186/s12967-022-03229-6

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