LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis

LncRNA PVT1 triggers Cyto-protective autophagy and promotes pancreatic ductal adenocarcinoma development via the miR-20a-5p/ULK1 Axis

Abstract Background Defective autophagy is thought to contribute to the pathogenesis of many diseases, including cancer. Human plasmacytoma variant translocation 1 (PVT1) is an oncogenic long non-coding RNA that has been identified as a prognostic biomarker in pancreatic ductal adenocarcinoma, but h...

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Bibliographic Details
Main Authors: Fengting Huang, Wenying Chen, Juanfei Peng, Yuanhua Li, Yanyan Zhuang, Zhe Zhu, Chunkui Shao, Wanling Yang, Herui Yao, Shineng Zhang
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Molecular Cancer
Subjects:
Long non-coding RNA
PVT1
Autophagy
ULK1
miR-20a-5p
Pancreatic ductal adenocarcinoma
Online Access:http://link.springer.com/article/10.1186/s12943-018-0845-6

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http://link.springer.com/article/10.1186/s12943-018-0845-6

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