Hierarchical association of COPD to principal genetic components of biological systems

Hierarchical association of COPD to principal genetic components of biological systems

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Many disease-causing genetic variants converge on common biological functions and pathways. Precisely how to incorporate pathway knowledge in genetic association studies is not yet clear, however. Previous approaches employ a two-step approach, in which a regular association test is first performed...

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Bibliographic Details
Main Authors: Daniel E. Carlin, Simon J. Larsen, Vikram Sirupurapu, Michael H. Cho, Edwin K. Silverman, Jan Baumbach, Trey Ideker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212185/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212185/?tool=EBI

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