Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function
Axonal swellings have been found on Purkinje cell axons in the cerebellum both during development and disease. The authors show that axons with swellings propagate action potentials with higher fidelity than those without and that mice with more axonal swellings learn cerebellar-related tasks better...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24390-4 |
| _version_ | 1819202674959056896 |
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| author | Daneck Lang-Ouellette Kim M. Gruver Amy Smith-Dijak François G. C. Blot Chloe A. Stewart Pauline de Vanssay de Blavous Connie H. Li Carter Van Eitrem Charlotte Rosen Phyllis L. Faust Martijn Schonewille Alanna J. Watt |
| author_facet | Daneck Lang-Ouellette Kim M. Gruver Amy Smith-Dijak François G. C. Blot Chloe A. Stewart Pauline de Vanssay de Blavous Connie H. Li Carter Van Eitrem Charlotte Rosen Phyllis L. Faust Martijn Schonewille Alanna J. Watt |
| author_sort | Daneck Lang-Ouellette |
| collection | DOAJ |
| description | Axonal swellings have been found on Purkinje cell axons in the cerebellum both during development and disease. The authors show that axons with swellings propagate action potentials with higher fidelity than those without and that mice with more axonal swellings learn cerebellar-related tasks better. |
| first_indexed | 2024-12-23T04:07:47Z |
| format | Article |
| id | doaj.art-ea0d8880874746698230d5c079b876ee |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T04:07:47Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ea0d8880874746698230d5c079b876ee2022-12-21T18:00:35ZengNature PortfolioNature Communications2041-17232021-07-0112111310.1038/s41467-021-24390-4Purkinje cell axonal swellings enhance action potential fidelity and cerebellar functionDaneck Lang-Ouellette0Kim M. Gruver1Amy Smith-Dijak2François G. C. Blot3Chloe A. Stewart4Pauline de Vanssay de Blavous5Connie H. Li6Carter Van Eitrem7Charlotte Rosen8Phyllis L. Faust9Martijn Schonewille10Alanna J. Watt11Biology Department, McGill UniversityBiology Department, McGill UniversityBiology Department, McGill UniversityErasmus University Medical CenterBiology Department, McGill UniversityBiology Department, McGill UniversityBiology Department, McGill UniversityBiology Department, McGill UniversityBiology Department, McGill UniversityDepartment of Pathology and Cell Biology, Columbia UniversityErasmus University Medical CenterBiology Department, McGill UniversityAxonal swellings have been found on Purkinje cell axons in the cerebellum both during development and disease. The authors show that axons with swellings propagate action potentials with higher fidelity than those without and that mice with more axonal swellings learn cerebellar-related tasks better.https://doi.org/10.1038/s41467-021-24390-4 |
| spellingShingle | Daneck Lang-Ouellette Kim M. Gruver Amy Smith-Dijak François G. C. Blot Chloe A. Stewart Pauline de Vanssay de Blavous Connie H. Li Carter Van Eitrem Charlotte Rosen Phyllis L. Faust Martijn Schonewille Alanna J. Watt Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function Nature Communications |
| title | Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function |
| title_full | Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function |
| title_fullStr | Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function |
| title_full_unstemmed | Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function |
| title_short | Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function |
| title_sort | purkinje cell axonal swellings enhance action potential fidelity and cerebellar function |
| url | https://doi.org/10.1038/s41467-021-24390-4 |
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