Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging.

Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging.

Aging increases susceptibility to infection, in part because thymic involution culminates in reduced naïve T-lymphocyte output. Thymic epithelial cells (TECs) are critical to ensure normal maturation of thymocytes and production of peripheral T cells. The forkhead-class transcription factor, encoded...

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Bibliographic Details
Main Authors: Jianfei Guo, Yan Feng, Peter Barnes, Fang-Fang Huang, Steven Idell, Dong-Ming Su, Homayoun Shams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3326029?pdf=render

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http://europepmc.org/articles/PMC3326029?pdf=render

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