EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity

EloA promotes HEL polyploidization upon PMA stimulation through enhanced ERK1/2 activity

Megakaryocytes (MKs) are the unique non-pathological cells that undergo polyploidization in mammals. The polyploid formation is critical for understanding the MK biology, and transcriptional regulation is involved in the differentiation and maturation of MKs. However, little is known about the funct...

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Bibliographic Details
Main Authors: Lanyue Hu, Weiwei Zhang, Zheng Xiang, Yali Wang, Cheng Zeng, Xiaojie Wang, Chengning Tan, Yichi Zhang, Fengjie Li, Yanni Xiao, Luping Zhou, Jiuxuan Li, Chun Wu, Yang Xiang, Lixin Xiang, Xiaomei Zhang, Xueying Wang, Wuchen Yang, Maoshan Chen, Qian Ran, Zhongjun Li, Li Chen
Format: Article
Language:English
Published: Taylor & Francis Group 2022-07-01
Series:Platelets
Subjects:
eloa
erk1/2
megakaryocytic difffferentiation
polyploidization
transcription elongation factor
Online Access:http://dx.doi.org/10.1080/09537104.2021.1988548

Internet

http://dx.doi.org/10.1080/09537104.2021.1988548

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