The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation

The inhibition of tamoxifen on UGT2B gene expression and enzyme activity in rat liver contribute to the estrogen homeostasis dysregulation

Abstract Background Tamoxifen treatment may induce dysregulation of estrogen homeostasis, leading to the occurrence of related adverse reactions. However, the potential mechanisms are still unclear. The purpose of the present study was to uncover whether tamoxifen treatment would act on estrogen met...

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Bibliographic Details
Main Authors: Zhixiang Hao, Jiahao Xu, Han Zhao, Wei Zhou, Zhao Liu, Shiqing He, Xiaoxing Yin, Bei Zhang, Zhongjian Wang, Xueyan Zhou
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Pharmacology and Toxicology
Subjects:
Breast cancer
Tamoxifen
Estrogens
Estrogen metabolizing enzyme
UGT2B
Online Access:https://doi.org/10.1186/s40360-022-00574-6

Internet

https://doi.org/10.1186/s40360-022-00574-6

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