Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

Antibodies targeting the neuraminidase active site inhibit influenza H3N2 viruses with an S245N glycosylation site

Antibodies that broadly inhibit influenza virus neuraminidase by binding to its active site could be therapeutic candidates, but circulating viruses have acquired a glycosylation site in that region. Here, the authors show that, while the S245N glycosylation site affects binding of tested monoclonal...

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Bibliographic Details
Main Authors: Daniel Stadlbauer, Meagan McMahon, Hannah L. Turner, Xueyong Zhu, Hongquan Wan, Juan Manuel Carreño, George O’Dell, Shirin Strohmeier, Zain Khalil, Marta Luksza, Harm van Bakel, Viviana Simon, Ali H. Ellebedy, Ian A. Wilson, Andrew B. Ward, Florian Krammer
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35586-7

Internet

https://doi.org/10.1038/s41467-022-35586-7

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