Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

Background Although estrogen receptor α (ERα) acts primarily as a transcription factor, it can also elicit membrane‐initiated steroid signaling. Pharmacological tools and transgenic mouse models previously highlighted the key role of ERα membrane‐initiated steroid signaling in 2 actions of estrogens...

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Bibliografiska uppgifter
Huvudupphovsmän: Emmanuel Guivarc'h, Mélissa Buscato, Anne‐Laure Guihot, Julie Favre, Emilie Vessières, Linda Grimaud, Jamal Wakim, Nada‐Joe Melhem, Rana Zahreddine, Marine Adlanmerini, Laurent Loufrani, Claude Knauf, John A. Katzenellenbogen, Benita S. Katzenellenbogen, Jean‐Michel Foidart, Pierre Gourdy, Françoise Lenfant, Jean‐François Arnal, Daniel Henrion, Coralie Fontaine
Materialtyp: Artikel
Språk:English
Publicerad: Wiley 2018-07-01
Serie:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Ämnen:
arteriolar remodeling
atherosclerosis
estrogen
hypertension
nuclear receptor
Länkar:https://www.ahajournals.org/doi/10.1161/JAHA.118.008950

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.118.008950

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