S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane

S-15176 Difumarate Salt Can Impair Mitochondrial Function through Inhibition of the Respiratory Complex III and Permeabilization of the Inner Mitochondrial Membrane

S-15176 difumarate salt, a derivative of the anti-ischemic metabolic drug trimetazidine, has been intensively studied for its impact on cellular metabolism in animal models of ischemia-reperfusion injury of the liver, heart, spinal cord, and other organs. Despite evidence of some reduction in oxidat...

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Bibliographic Details
Main Authors: Natalia V. Belosludtseva, Vlada S. Starinets, Alena A. Semenova, Anastasia D. Igoshkina, Mikhail V. Dubinin, Konstantin N. Belosludtsev
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biology
Subjects:
S-15176
mitochondria
mitochondrial membrane potential
mitochondrial respiration
electron transport chain
mitochondrial membrane permeabilization
Online Access:https://www.mdpi.com/2079-7737/11/3/380

Internet

https://www.mdpi.com/2079-7737/11/3/380

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