CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding

CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding

Both hypothalamic microglial inflammation and melanocortin pathway dysfunction contribute to diet-induced obesity (DIO) pathogenesis. Previous studies involving models of altered microglial signaling demonstrate altered DIO susceptibility with corresponding POMC neuron cytological changes, suggestin...

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Bibliographic Details
Main Authors: Jineta Banerjee, Mauricio D. Dorfman, Rachael Fasnacht, John D. Douglass, Alice C. Wyse-Jackson, Andres Barria, Joshua P. Thaler
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
microglia
fractalkine
POMC neurons
obesity
melanocortin system
Online Access:https://www.mdpi.com/1422-0067/23/12/6380

Internet

https://www.mdpi.com/1422-0067/23/12/6380

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