Verapamil hydrochloride loaded solid lipid nanoparticles: Preparation, optimization, characterisation, and assessment of cardioprotective effect in experimental model of myocardial infarcted rats

Verapamil hydrochloride loaded solid lipid nanoparticles: Preparation, optimization, characterisation, and assessment of cardioprotective effect in experimental model of myocardial infarcted rats

Verapamil, a calcium channel blocker has poor bioavailability (20–30%) owing to extensive hepatic first-pass metabolism. Hence, the major objective of this research was to improve the oral bioavailability of Verapamil by Solid Lipid Nanoparticles (V-SLNs) using high shear homogenization and ultrason...

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Bibliographic Details
Main Authors: Yogeeta.O. Agrawal, Muzammil Husain, Kiran D. Patil, Vishal Sodgir, Tulshidas S. Patil, Vinit V. Agnihotri, Hitendra S. Mahajan, Charu Sharma, Shreesh Ojha, Sameer N. Goyal
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Solid lipid nanoparticles
Verapamil
Factorial design
Isoproterenol
Myocardial necrosis
Pharmacokinetic
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222008186

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http://www.sciencedirect.com/science/article/pii/S0753332222008186

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