Survival of an Islet Allograft Deficient in iNOS after Implantation into Diabetic NOD Mice
Proinflammatory cytokines play a major role in rejection of pancreatic islet allografts and in type 1 diabetes (T1D). In rodent islets, exposure to IL-1β alone or combined with IFN-γ induces expression of inducible nitric oxide synthase (iNOS). Inhibition of iNOS or a deletion of the iNOS gene has b...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2006-09-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/000000006783981495 |