Development of an antibody-ligand fusion protein scFvCD16A-sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells

Development of an antibody-ligand fusion protein scFvCD16A-sc4-1BBL in Komagataella phaffii with stimulatory activity for Natural Killer cells

Abstract Background Natural killer (NK) cell-based immunotherapies have demonstrated substantial potential for the treatment of hematologic malignancies. However, its application is limited due to the difficulty in the production of a large number of NK cells in vitro and the insufficient therapeuti...

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Bibliographic Details
Main Authors: Yangyang Li, Siqi Xie, Minhua Chen, Hao Li, Yehai Wang, Yan Fan, Kang An, Yu Wu, Weihua Xiao
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Microbial Cell Factories
Subjects:
Natural killer cell
Immunotherapy
CD16A
4-1BBL
Pichia pastoris
Antibody-ligand fusion protein
Online Access:https://doi.org/10.1186/s12934-023-02082-6

Internet

https://doi.org/10.1186/s12934-023-02082-6

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