CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching

Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our...

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Bibliographic Details
Main Authors: Fatemeh Movahedi Motlagh, Hamid Reza Soleimanpour‐Lichaei, Mehdi Shamsara, Azadeh Etemadzadeh, Mohammad Hossein Modarressi
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2023-11-01
Series:Advanced Pharmaceutical Bulletin
Subjects:
crispr/cas9
beta hemoglobinopathies
fetal hemoglobin
globin switching
bcl11a knockdown
Online Access:https://apb.tbzmed.ac.ir/PDF/apb-13-799.pdf

Internet

https://apb.tbzmed.ac.ir/PDF/apb-13-799.pdf

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