Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region

Disruption of neurogenesis and cortical development in transgenic mice misexpressing Olig2, a gene in the Down syndrome critical region

The basic helix-loop-helix (bHLH) transcription factor Olig2 is crucial for mammalian central nervous system development. Human ortholog OLIG2 is located in the Down syndrome critical region in trisomy 21. To investigate the effect of Olig2 misexpression on brain development, we generated a developm...

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Bibliographic Details
Main Authors: Wei Liu, Hui Zhou, Lei Liu, Chuntao Zhao, Yaqi Deng, Lina Chen, Laiman Wu, Nicole Mandrycky, Christopher T. McNabb, Yuanbo Peng, Perry N. Fuchs, Jie Lu, Volney Sheen, Mengsheng Qiu, Meng Mao, Q. Richard Lu
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Neurobiology of Disease
Subjects:
Olig2
Down syndrome
Neural cell death
Cortical progenitor proliferation
Neurogenesis
Cortical development
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611500056X

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http://www.sciencedirect.com/science/article/pii/S096999611500056X

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