Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

Estrogen-related receptor gamma regulates mitochondrial and synaptic genes and modulates vulnerability to synucleinopathy

Abstract Many studies implicate mitochondrial dysfunction as a key contributor to cell loss in Parkinson disease (PD). Previous analyses of dopaminergic (DAergic) neurons from patients with Lewy-body pathology revealed a deficiency in nuclear-encoded genes for mitochondrial respiration, many of whic...

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Bibliographic Details
Main Authors: S. N. Fox, L. J. McMeekin, C. H. Savage, K. L. Joyce, S. M. Boas, M. S. Simmons, C. B. Farmer, J. Ryan, L. Pereboeva, K. Becker, J. Auwerx, S. Sudarshan, J. Ma, A. Lee, R. C. Roberts, D. K. Crossman, A. Kralli, R. M. Cowell
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00369-w

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https://doi.org/10.1038/s41531-022-00369-w

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