Carob leaf polyphenols trigger intrinsic apoptotic pathway and induce cell cycle arrest in colon cancer cells

Carob leaf polyphenols trigger intrinsic apoptotic pathway and induce cell cycle arrest in colon cancer cells

Chemoprevention of Colorectal cancer (CRC) is the major concern for improving public health. We investigated the protective effects of carob, Ceratonia siliqua L., leaf polyphenols (CLP) against CRC. Phenolic content analysis showed that CLP is enriched with gallic acid and m-coumaric acid. We obser...

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Bibliographic Details
Main Authors: Fatima Zahra Ghanemi, Meriem Belarbi, Aurélie Fluckiger, Abdelhafid Nani, Adélie Dumont, Charlotte De Rosny, Ikram Aboura, Amira Sayed Khan, Babar Murtaza, Chahid Benammar, Boucif Farid Lahfa, Danish Patoli, Dominique Delmas, Cédric Rébé, Lionel Apétoh, Naim Akhtar Khan, François Ghringhelli, Mickael Rialland, Aziz Hichami
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Journal of Functional Foods
Subjects:
Carob (Ceratonia siliqua L.)
Polyphenols
Colorectal cancer
Caspases
Apoptosis
Cell cycle arrest
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464617301512

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http://www.sciencedirect.com/science/article/pii/S1756464617301512

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