Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumour microenvironment
The immune system has a key role to play in controlling cancer initiation and progression. T cell activation, which is central to anti-tumour immune responses, coincides with changes in cellular metabolism. Naïve T cells predominantly require an ATP generating metabolic profile, whereas proliferatin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00107/full |