Rab7 localized on zymogen granules is involved in maturation but not in autophagy or regulated exocytosis in pancreatic acinar cells

Abstract Rab7 is known to function in the autophagy and endocytosis pathways in eukaryocytes and is related to various diseases. We recently reported that Rab7 plays a protective role against acute pancreatitis. However, its physiological function in exocytic cells remains unclear. Therefore, we inv...

Full description

Bibliographic Details
Main Authors: Kenichi Takahashi, Hirosato Mashima, Masanari Sekine, Takeshi Uehara, Takeharu Asano, Ge-Hong Sun-Wada, Yoh Wada, Hirohide Ohnishi
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-49520-4