ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages

ALOX5 contributes to glioma progression by promoting 5-HETE-mediated immunosuppressive M2 polarization and PD-L1 expression of glioma-associated microglia/macrophages

Background Oxylipin metabolism plays an essential role in glioma progression and immune modulation in the tumor microenvironment. Lipid metabolic reprogramming has been linked to macrophage remodeling, while the understanding of oxylipins and their catalyzed enzymes lipoxygenases in the regulation o...

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Bibliographic Details
Main Authors: Tao Chen, Jiayi Zhou, Jiangang Liu, Jianwei Wang, Zhuohao Liu, Jie Mao, Dinglan Wu, Xiaosheng He, Chenci Wang, Zhengwei Wang, Jiani Lin, Tingzheng Pan, Hongchao Xu
Format: Article
Language:English
Published: BMJ Publishing Group 2024-08-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/8/e009492.full

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https://jitc.bmj.com/content/12/8/e009492.full

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