The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

<p>Abstract</p> <p>Accumulating evidence suggests that neurons prone to degeneration in Alzheimer's Disease (AD) exhibit evidence of re-entry into an aberrant mitotic cell cycle. Our laboratory recently demonstrated that, in a genomic <it>amyloid precursor protein </i...

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Bibliographic Details
Main Authors: Herrup Karl, Chludzinski Alexandra, Miller Megan, Bhaskar Kiran, Zagorski Michael, Lamb Bruce T
Format: Article
Language:English
Published: BMC 2009-03-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/4/1/14