Berberine Attenuates Cell Motility via Inhibiting Inflammation-Mediated Lysyl Hydroxylase-2 and Glycolysis

Berberine Attenuates Cell Motility via Inhibiting Inflammation-Mediated Lysyl Hydroxylase-2 and Glycolysis

Lysyl hydroxylase-2 (LH2) involves in the hydroxylation of telopeptide lysine residues during collagen deposition. Recent studies indicate that interleukin (IL)-6 generated by the chronic inflammation disease may trigger the LH2 expression to accelerate cell motility. Berberine is the alkaloid deriv...

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Bibliographic Details
Main Authors: Yishan Du, Muhammad Khan, Nana Fang, Fang Ma, Hongzhi Du, Zhenya Tan, Hua Wang, Shi Yin, Xiaohui Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
berberine
IL-6
LH2
motility
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.856777/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.856777/full

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