Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

Serine ADP-ribosylation marks nucleosomes for ALC1-dependent chromatin remodeling

Serine ADP-ribosylation (ADPr) is a DNA damage-induced post-translational modification catalyzed by the PARP1/2:HPF1 complex. As the list of PARP1/2:HPF1 substrates continues to expand, there is a need for technologies to prepare mono- and poly-ADP-ribosylated proteins for biochemical interrogation....

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Bibliographic Details
Main Authors: Jugal Mohapatra, Kyuto Tashiro, Ryan L Beckner, Jorge Sierra, Jessica A Kilgore, Noelle S Williams, Glen Liszczak
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
DNA damage response
post-translational modifications
chemical biology
protein semi-synthesis
PARP
HPF1
Online Access:https://elifesciences.org/articles/71502

Internet

https://elifesciences.org/articles/71502

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