Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening

Novel Histone Deacetylase Inhibitors and HIV-1 Latency-Reversing Agents Identified by Large-Scale Virtual Screening

Current antiretroviral therapies used for HIV management do not target latent viral reservoirs in humans. The experimental “shock-and-kill” therapeutic approach involves use of latency-reversal agents (LRAs) that reactivate HIV expression in reservoir-containing cells, followed by infected cell elim...

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Bibliographic Details
Main Authors: Donya Naz Divsalar, Conrad Veranso Simoben, Cole Schonhofer, Khumoekae Richard, Wolfgang Sippl, Fidele Ntie-Kang, Ian Tietjen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Pharmacology
Subjects:
virtual screening
histone deacetylase
histone deacetylase inhibitor
HIV
latency reversal
drug discovery
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00905/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00905/full

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