Dynamic Characterization of the Human Heme Nitric Oxide/Oxygen (HNOX) Domain under the Influence of Diatomic Gaseous Ligands

Dynamic Characterization of the Human Heme Nitric Oxide/Oxygen (HNOX) Domain under the Influence of Diatomic Gaseous Ligands

Soluble guanylate cyclase (sGC) regulates numerous physiological processes. The &#946; subunit Heme Nitric Oxide/Oxygen (HNOX) domain makes this protein sensitive to small gaseous ligands. The structural basis of the activation mechanism of sGC under the influence of ligands (NO, O<sub>2&l...

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Bibliographic Details
Main Authors: Rana Rehan Khalid, Abdul Rauf Siddiqi, Efstratios Mylonas, Arooma Maryam, Michael Kokkinidis
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
quantum calculations
soluble guanylate cyclase
molecular dynamics simulations
metal center parameter builder
hydrogen bond occupancy
principal component analysis
Online Access:https://www.mdpi.com/1422-0067/20/3/698

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https://www.mdpi.com/1422-0067/20/3/698

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