MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway

MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway

X-linked hypophosphatemia (XLH), an inheritable form of rickets is caused due to mutation in Phex gene. Several factors are linked to the disease’s aetiology, including non-coding RNA molecules (miRNAs), which are key post-transcriptional regulators of gene expression and play a significant role in...

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Bibliographic Details
Main Authors: Alok Tripathi, Aijaz A. John, Deepak Kumar, Saurabh Kumar Kaushal, Devendra Pratap Singh, Nazim Husain, Jayanta Sarkar, Divya Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Endocrinology
Subjects:
microRNA
X-linked hypophosphatemia
PHEX
LRP-6
AKAP-3
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.977347/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.977347/full

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