Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs

Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs

The human genome encodes 850 G protein-coupled receptors (GPCRs), half of which are considered potential drug targets. GPCRs transduce extracellular stimuli into a plethora of vital physiological processes. Consequently, GPCRs are an attractive drug target class. This is underlined by the fact that...

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Bibliographic Details
Main Authors: Toon Laeremans, Zara A. Sands, Pieter Claes, Ann De Blieck, Stephane De Cesco, Sarah Triest, Andreas Busch, David Felix, Abhinav Kumar, Veli-Pekka Jaakola, Christel Menet
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
active state
biosensor
ConfoBody
conformation
conformer
GPCR
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.863099/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2022.863099/full

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