The synthetic oleanane triterpenoid CDDO‐2P‐Im binds GRP78/BiP to induce unfolded protein response‐mediated apoptosis in myeloma

The synthetic oleanane triterpenoid CDDO‐2P‐Im binds GRP78/BiP to induce unfolded protein response‐mediated apoptosis in myeloma

Synthetic oleanane triterpenoids (SOTs) are small molecules with broad anticancer properties. A recently developed SOT, 1‐[2‐cyano‐3,12‐dioxooleana‐1,9(11)‐dien‐28‐oyl]‐4(‐pyridin‐2‐yl)‐1H‐imidazole (CDDO‐2P‐Im or ‘2P‐Im’), exhibits enhanced activity and improved pharmacokinetics over CDDO‐Im, a pre...

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Bibliographic Details
Main Authors: George Luo, Kristin Aldridge, Toby Chen, Vivek Aslot, Byung‐Gyu Kim, Eun Hyang Han, Neelima Singh, Sai Li, Tsan Sam Xiao, Michael B. Sporn, John J. Letterio
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Molecular Oncology
Subjects:
apoptosis
CDDO‐2P‐Im
GRP78
myeloma
triterpenoid
UPR
Online Access:https://doi.org/10.1002/1878-0261.13447

Internet

https://doi.org/10.1002/1878-0261.13447

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