Development of Cellular Models to Study Efficiency and Safety of Gene Edition by Homologous Directed Recombination Using the CRISPR/Cas9 System

Development of Cellular Models to Study Efficiency and Safety of Gene Edition by Homologous Directed Recombination Using the CRISPR/Cas9 System

In spite of the enormous potential of CRISPR/Cas in basic and applied science, the levels of undesired genomic modifications cells still remain mostly unknown and controversial. Nowadays, the efficiency and specificity of the cuts generated by CRISPR/Cas is the main concern. However, there are also...

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Bibliographic Details
Main Authors: Sabina Sánchez-Hernández, Araceli Aguilar-González, Beatriz Guijarro-Albaladejo, Noelia Maldonado-Pérez, Iris Ramos-Hernández, Marina Cortijo-Gutiérrez, Rosario María Sánchez Martín, Karim Benabdellah, Francisco Martin
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
models
DNA donor
on-target integration
homologous directed recombination (HDR)
efficacy
safety
Online Access:https://www.mdpi.com/2073-4409/9/6/1492

Internet

https://www.mdpi.com/2073-4409/9/6/1492

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