Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons

Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons

Abstract Numerous studies have shown a strong correlation between the number of neurofibrillary tangles of the tau protein and Alzheimer's disease progression, making the quantitative detection of tau very promising from a clinical point of view. However, the lack of highly reliable fluorescent...

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Bibliographic Details
Main Authors: Alessandro Soloperto, Deborah Quaglio, Paola Baiocco, Isabella Romeo, Mattia Mori, Matteo Ardini, Caterina Presutti, Ida Sannino, Silvia Ghirga, Antonia Iazzetti, Rodolfo Ippoliti, Giancarlo Ruocco, Bruno Botta, Francesca Ghirga, Silvia Di Angelantonio, Alberto Boffi
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-09016-z

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https://doi.org/10.1038/s41598-022-09016-z

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