Conformational ensemble of the TNF-derived peptide solnatide in solution

Conformational ensemble of the TNF-derived peptide solnatide in solution

Tumor necrosis factor (TNF) is a homotrimer that has two spatially distinct binding regions, three lectin-like domains (LLD) at the TIP of the protein and three basolaterally located receptor-binding sites, the latter of which are responsible for the inflammatory and cell death-inducing properties o...

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Bibliographic Details
Main Authors: Pau Martin-Malpartida, Silvia Arrastia-Casado, Josep Farrera-Sinfreu, Rudolf Lucas, Hendrik Fischer, Bernhard Fischer, Douglas C. Eaton, Susan Tzotzos, Maria J. Macias
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Pulmonary edema
Alveolar fluid clearance
Tumor necrosis factor
Amiloride-sensitive epithelial sodium channel
ENaC
Amphipathic helix
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022001489

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http://www.sciencedirect.com/science/article/pii/S2001037022001489

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