Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement

Development of olanzapine solid dispersion by spray drying technique using screening design for solubility enhancement

Introduction: Olanzapine (OLZ) is a psychotropic class drug commonly used to treat schizophrenia, bipolar disorder, and acute manic episodes. It has less water solubility, resulting in a slow dissolution rate and oral bioavailability. Therefore, the development in oral dosage forms is required to e...

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Bibliographic Details
Main Authors: Leena Patil, Umakant Verma, Rahul Rajput, Pritam Patil, Anniruddha Chaterjee, Jitendra B. Naik
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2023-10-01
Series:ADMET and DMPK
Subjects:
Olanzapine
Solubility
Spray Drying
Plackett–Burman design
Solid dispersion
Online Access:https://pub.iapchem.org/ojs/index.php/admet/article/view/1998

Internet

https://pub.iapchem.org/ojs/index.php/admet/article/view/1998

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