Insulin BBB pharmacokinetics in young apoE male and female transgenic mice.

In addition to age, apolipoprotein E4 (E4), female sex, or a combination of both synergistically increase the risk for the development of Alzheimer's disease (AD). Why these risk factors predispose an individual to developing AD later in life is the target of the current investigation. Central...

Full description

Bibliographic Details
Main Authors: Elizabeth M Rhea, Eileen Ruth S Torres, Jacob Raber, William A Banks
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0228455