Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia

Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia

Abstract Background Chronic cerebral ischemia induces white matter injury (WMI) contributing to cognitive decline. Both astrocytes and microglia play vital roles in the demyelination and remyelination processes, but the underlying mechanism remains unclear. This study aimed to explore the influence...

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Bibliographic Details
Main Authors: Qian Cao, Jian Chen, Zhi Zhang, Shu Shu, Yi Qian, Lixuan Yang, Lushan Xu, Yuxin Zhang, Xinyu Bao, Shengnan Xia, Haiyan Yang, Yun Xu, Shuwei Qiu
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Neuroinflammation
Subjects:
CXCL5
BCAS
Astrocyte
Microglia
Phagocytosis
Online Access:https://doi.org/10.1186/s12974-023-02780-3

Internet

https://doi.org/10.1186/s12974-023-02780-3

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