Qualitative Assay to Detect Dopamine Release by Ligand Action on Nicotinic Acetylcholine Receptors

A pheochromocytoma of the rat adrenal medulla derived (a.k.a. PC12) cell-based assay for dopamine measurement by luminescence detection was customized for the qualitative evaluation of agonists and antagonists of nicotinic acetylcholine receptors (nAChRs). The assay mechanism begins with ligand bind...

Full description

Bibliographic Details
Main Authors: Leanna A. Marquart, Matthew W. Turner, Owen M. McDougal
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Toxins
Subjects:
Online Access:https://www.mdpi.com/2072-6651/11/12/682