Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation

Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation

Abstract Background Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and degradation. However, the role of SYVN1 in the pathogenesis of asthma is...

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Bibliographic Details
Main Authors: Bing Dai, Si Liu, Wenxin Shen, Li Chen, Qianlan Zhou, Lina Han, Qinzhen Zhang, Lishen Shan
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Biological Research
Subjects:
SYVN1
SIRT2
Ubiquitination
Endoplasmic reticulum stress
Epithelial-mesenchymal transition
Asthma
Online Access:https://doi.org/10.1186/s40659-023-00478-7

Internet

https://doi.org/10.1186/s40659-023-00478-7

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