Persistent DNA-break potential near telomeres increases initiation of meiotic recombination on short chromosomes

Meiotic recombination density is increased on shorter chromosomes. Here the authors show that recombination initiation continues near all chromosome ends long after interstitial regions become quiescent in a process that proportionally benefits short chromosomes.

Bibliographic Details
Main Authors: Vijayalakshmi V. Subramanian, Xuan Zhu, Tovah E. Markowitz, Luis A. Vale-Silva, Pedro A. San-Segundo, Nancy M. Hollingsworth, Scott Keeney, Andreas Hochwagen
Format: Article
Language:English
Published: Nature Portfolio 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08875-x