Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells

Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells

The oncogenic role of nuclear LIM domain only 2 (LMO2) as a transcriptional regulator is well established, but its function in the cytoplasm is largely unknown. Here, we identified LMO2 as a cytoplasmic activator for signal transducer and activator of transcription 3 (STAT3) signaling in glioma stem...

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Bibliographic Details
Main Authors: Cheol Gyu Park, Sang-Hun Choi, Seon Yong Lee, Kiyoung Eun, Min Gi Park, Junseok Jang, Hyeon Ju Jeong, Seong Jin Kim, Sohee Jeong, Kanghun Lee, Hyunggee Kim
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
cancer stem cells
glioblastoma
glioma stem cells
LMO2
STAT3
Online Access:https://www.mdpi.com/2073-4409/11/13/2031

Internet

https://www.mdpi.com/2073-4409/11/13/2031

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