Recombinant Adeno-Associated Viral Vector-Mediated Gene Transfer of <i>hTBX18</i> Generates Pacemaker Cells from Ventricular Cardiomyocytes

Recombinant Adeno-Associated Viral Vector-Mediated Gene Transfer of <i>hTBX18</i> Generates Pacemaker Cells from Ventricular Cardiomyocytes

Sinoatrial node dysfunction can manifest as bradycardia, leading to symptoms of syncope and sudden cardiac death. Electronic pacemakers are the current standard of care but are limited due to a lack of biological chronotropic control, cost of revision surgeries, and risk of lead- and device-related...

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Bibliographic Details
Main Authors: Melad Farraha, Renuka Rao, Sindhu Igoor, Thi Y. L. Le, Michael A. Barry, Christopher Davey, Cindy Kok, James J.H. Chong, Eddy Kizana
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
adeno-associated viral vector
cardiomyocytes
gene therapy
heart
hTBX18
pacemaker cells
Online Access:https://www.mdpi.com/1422-0067/23/16/9230

Internet

https://www.mdpi.com/1422-0067/23/16/9230

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