Recombinant Adeno-Associated Viral Vector-Mediated Gene Transfer of <i>hTBX18</i> Generates Pacemaker Cells from Ventricular Cardiomyocytes
Sinoatrial node dysfunction can manifest as bradycardia, leading to symptoms of syncope and sudden cardiac death. Electronic pacemakers are the current standard of care but are limited due to a lack of biological chronotropic control, cost of revision surgeries, and risk of lead- and device-related...
Main Authors: | Melad Farraha, Renuka Rao, Sindhu Igoor, Thi Y. L. Le, Michael A. Barry, Christopher Davey, Cindy Kok, James J.H. Chong, Eddy Kizana |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-08-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/23/16/9230 |
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