Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase

Metabolomics-Driven Elucidation of Cellular Nitrate Tolerance Reveals Ascorbic Acid Prevents Nitroglycerin-Induced Inactivation of Xanthine Oxidase

Glyceryl trinitrate (GTN) has found widespread use for the treatment of angina pectoris, a pathological condition manifested by chest pain resulting from insufficient blood supply to the heart. Metabolic conversion of GTN, a nitric oxide (NO) pro-drug, into NO induces vasodilation and improves blood...

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Bibliographic Details
Main Authors: Elizabeth Rose Axton, Eleonso Cristobal, Jaewoo Choi, Cristobal L. Miranda, Jan Frederik Stevens
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Pharmacology
Subjects:
nitrate tolerance
nitroglycerin
xanthine oxidase
ascorbic acid
nitric oxide
metabolomics
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01085/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01085/full

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