Adipocyte NR1D1 dictates adipose tissue expansion during obesity

Adipocyte NR1D1 dictates adipose tissue expansion during obesity

The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observed under adipocyte-selective deletion (Nr1d1Flox2-6:...

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Bibliographic Details
Main Authors: Ann Louise Hunter, Charlotte E Pelekanou, Nichola J Barron, Rebecca C Northeast, Magdalena Grudzien, Antony D Adamson, Polly Downton, Thomas Cornfield, Peter S Cunningham, Jean-Noel Billaud, Leanne Hodson, Andrew SI Loudon, Richard D Unwin, Mudassar Iqbal, David W Ray, David A Bechtold
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-08-01
Series:eLife
Subjects:
circadian clock
energy metabolism
obesity
adipose
Rev-erb-alpha
Rev-erbα
Online Access:https://elifesciences.org/articles/63324

Internet

https://elifesciences.org/articles/63324

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