Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis

Abstract Bioenergetic failure and oxidative stress are common pathological hallmarks of amyotrophic lateral sclerosis (ALS), but whether these could be targeted effectively for novel therapeutic intervention needs to be determined. One of the reported contributors to ALS pathology is mitochondrial d...

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Bibliographic Details
Main Authors: Amit U Joshi, Nay L Saw, Hannes Vogel, Anna D Cunnigham, Mehrdad Shamloo, Daria Mochly‐Rosen
Format: Article
Language:English
Published: Springer Nature 2018-03-01
Series:EMBO Molecular Medicine
Subjects:
amyotrophic lateral sclerosis
dynamin‐related protein 1
fission 1
mitochondrial dysfunction
Protein–Protein interactions
Online Access:https://doi.org/10.15252/emmm.201708166

Internet

https://doi.org/10.15252/emmm.201708166

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