A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations

For decades, the mechanism of skeletal patterning along a proximal-distal axis has been an area of intense inquiry. Here, we examine the development of the ribs, simple structures that in most terrestrial vertebrates consist of two skeletal elements—a proximal bone and a distal cartilage portion. Wh...

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Bibliographic Details
Main Authors: Jennifer L Fogel, Daniel L Lakeland, In Kyoung Mah, Francesca V Mariani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/29144